AP4E1

Across TCGA cell cohorts, AP4E1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP4E1-associated genes across cancer lineages are C14orf180, REG3G, and MS4A2. Each is linked with AP4E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP4E1-to-partner and partner-to-AP4E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf180 grouped by AP4E1-low versus AP4E1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4E1→partner) and Y-score (partner→AP4E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C14orf180 →	+0.151	+3.155	<.001	.008	3	2
BLOOD_Lymphoma	REG3G →	+0.026	+4.867	.004	.009	3	1
BLOOD_Lymphoma	MS4A2 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OR14A16 →	+0.016	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP4-11 →	+0.038	+5.209	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

C14orf180 by AP4E1 expression — LARGE_INTESTINE

Explore this box plot interactively →