AP4B1

Across TCGA patient cohorts, AP4B1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,318 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AP4B1-associated genes across cancer lineages are TREM1, PHOSPHO2, and HLF. Each is linked with AP4B1 in more than 4 cancer types. Because this analysis shows association rather than direction, both AP4B1-to-partner and partner-to-AP4B1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AP4B1 versus TREM1 in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4B1→partner) and Y-score (partner→AP4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TREM1 →	+1.615	+0.290	<.001	<.001	3	5
HNSC	PHOSPHO2 →	-0.625	-0.189	.001	.001	3	5
LUAD	HLF →	-1.263	-0.136	<.001	.005	3	4
LSCC	DSE →	+0.575	+0.171	.003	.003	3	4
LSCC	CNNM1 →	-0.823	-0.103	<.001	.004	3	4
HNSC	S100A8 →	+2.025	+0.281	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,318 associations by consensus.

AP4B1 vs TREM1 — GBM

Explore this scatter interactively →