AP3D1

Across TCGA pan-cancer cohorts, AP3D1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated AP3D1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AP3D1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated AP3D1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where AP3D1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.494	.016	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
HNSC	DFS	Quartile	III,IV	0.532	0.825	.011	5	view →
GBM	OS	Quartile	All	0.308	0.638	.025	3	view →
LUAD	DFS	Tertile	All	0.898	1.000	.023	3	view →
CCRCC	OS	Tertile	All	0.672	1.000	.028	1	view →
LSCC	DFS	Median	All	0.894	0.518	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

AP3D1–UCEC (OS)

Open the UCEC breakdown →