AP3D1

Across TCGA pan-cancer cohorts, AP3D1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of AP3D1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AP3D1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AP3D1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where AP3D1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AP3D1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.628	<.001	11	view →
COAD	All	III,IV	+0.589	<.001	10	view →
LIHC	Female	II,III,IV	+1.336	<.001	9	view →
STAD	Male	II,III,IV	+0.950	<.001	8	view →
THCA	Male	II,III,IV	−0.525	<.001	8	view →
BRCA	All	II,III,IV	+0.330	<.001	6	view →
LUAD	All	All	+0.315	<.001	6	view →
CHOL	Male	All	+2.020	<.001	5	view →
LUSC	Male	II,III,IV	+0.625	<.001	5	view →
KIRP	Female	All	+0.512	.009	4	view →
ESCA	All	All	+0.631	.015	3	view →
READ	All	III,IV	+0.794	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

AP3D1–HNSC

Open the HNSC breakdown →