AP3D1

Across TCGA patient cohorts, AP3D1 mutation is significantly associated with the RNA expression of many other genes, with 4,322 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP3D1-associated genes across cancer lineages are ADAM10, GEMIN4, and CENPM. Each is linked with AP3D1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AP3D1-to-partner and partner-to-AP3D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM10 grouped by AP3D1-low versus AP3D1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3D1→partner) and Y-score (partner→AP3D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADAM10 →	+0.438	+2.263	<.001	.004	3	4
UCEC	GEMIN4 →	+0.426	+2.928	.002	<.001	3	4
UCEC	CENPM →	+0.523	+3.917	.001	<.001	3	3
UCEC	GZMH →	+1.018	+2.454	<.001	<.001	3	3
UCEC	GSR →	+0.505	+3.606	.004	.001	3	3
UCEC	CACTIN →	+0.443	+2.443	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,322 associations by consensus.

ADAM10 by AP3D1 expression — COAD

Explore this box plot interactively →