AP3D1

Across TCGA patient cohorts, AP3D1 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. COAD shows the largest number of these associations.

The most reproducible AP3D1-associated genes across cancer lineages are ACVRL1, ATM, and Caspase-7-cleavedD198. Each is linked with AP3D1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AP3D1-to-partner and partner-to-AP3D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by AP3D1-low versus AP3D1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3D1→partner) and Y-score (partner→AP3D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ACVRL1 →	-0.196	-3.152	.049	.019	3	3
UCEC	ATM →	-0.557	-2.571	<.001	.010	3	3
COAD	Caspase-7-cleavedD198 →	+1.105	+2.321	<.001	.005	3	3
BLCA	Rictor →	-0.874	-3.169	.045	.019	3	2
COAD	EGFR_pY1068 →	-0.360	-3.584	<.001	.002	3	2
COAD	mTOR_pS2448 →	-0.150	-3.572	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

ACVRL1 by AP3D1 expression — BLCA

Explore this box plot interactively →