AP3D1

Across TCGA cell cohorts, AP3D1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,113 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AP3D1-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Cytoplasm protein quality control, and Regulation of autophagosome maturation. Each is linked with AP3D1 in more than 17 cancer types. Because this analysis shows association rather than direction, both AP3D1-to-partner and partner-to-AP3D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by AP3D1-low versus AP3D1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3D1→partner) and Y-score (partner→AP3D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.164	+0.609	<.001	<.001	3	18
BONE	Cytoplasm protein quality control →	+0.135	+0.607	.004	.002	3	17
LARGE_INTESTINE	Regulation of autophagosome maturation →	+0.083	+0.759	<.001	<.001	3	15
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.183	+0.654	<.001	.001	3	15
LIVER	Negative regulation of protein localization to chromatin →	+0.171	+1.083	<.001	.001	3	14
SOFT_TISSUE	Cytosolic transport →	+0.059	+0.590	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,113 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by AP3D1 expression — LUNG_SCLC

Explore this box plot interactively →