AP3D1

Across TCGA cell cohorts, AP3D1 mutation is significantly associated with the RNA expression of many other genes, with 1,233 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP3D1-associated genes across cancer lineages are RCVRN, SNTG2, and PPP4R3A. Each is linked with AP3D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP3D1-to-partner and partner-to-AP3D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCVRN grouped by AP3D1-low versus AP3D1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3D1→partner) and Y-score (partner→AP3D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RCVRN →	+0.060	+5.087	<.001	.004	3	2
BLOOD_Leukemia	SNTG2 →	+1.224	+3.491	<.001	.009	3	2
LARGE_INTESTINE	PPP4R3A →	+0.423	+2.588	.005	.004	3	2
LARGE_INTESTINE	GPS2 →	+0.490	+3.131	.005	.008	3	2
LARGE_INTESTINE	EDEM1 →	+0.653	+3.067	.001	.009	3	2
LARGE_INTESTINE	WRAP53 →	+0.697	+3.628	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,233 associations by consensus.

RCVRN by AP3D1 expression — URINARY_TRACT

Explore this box plot interactively →