AP2S1

Across TCGA pan-cancer cohorts, AP2S1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AP2S1 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AP2S1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AP2S1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

COAD, LUAD, and PDAC are the cancer types where AP2S1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	0.493	0.944	.031	18	view →
LUAD	DFS	Quartile	III,IV	0.276	0.948	.006	11	view →
PDAC	OS	Quartile	II,III,IV	0.772	1.000	.008	9	view →
HNSC	DFS	Tertile	All	0.932	1.000	.020	4	view →
GBM	OS	Tertile	All	0.937	0.784	.025	2	view →
CCRCC	OS	Median	III,IV	0.713	0.920	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AP2S1–COAD (DFS)

Open the COAD breakdown →