AP2S1

Across TCGA pan-cancer cohorts, AP2S1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of AP2S1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AP2S1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AP2S1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where AP2S1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AP2S1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.769	<.001	12	view →
HNSC	Male	All	+0.682	<.001	11	view →
BLCA	Male	All	+0.972	<.001	10	view →
COAD	Female	II,III,IV	+0.691	<.001	10	view →
STAD	All	II,III,IV	+0.654	<.001	9	view →
LUSC	Female	II,III,IV	+1.124	<.001	8	view →
KIRP	All	III,IV	+0.615	.001	8	view →
LIHC	Female	II,III,IV	+0.840	<.001	7	view →
UCEC	All	III,IV	+1.404	<.001	6	view →
BRCA	All	III,IV	+0.988	<.001	6	view →
LUAD	All	III,IV	+0.551	<.001	6	view →
THCA	Female	II,III,IV	+0.446	.013	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

AP2S1–KIRC

Open the KIRC breakdown →