AP2S1

Across TCGA patient cohorts, AP2S1 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP2S1-associated genes across cancer lineages are RN7SL592P, RN7SL237P, and MIR3192. Each is linked with AP2S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP2S1-to-partner and partner-to-AP2S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL592P grouped by AP2S1-low versus AP2S1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2S1→partner) and Y-score (partner→AP2S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL592P →	+0.365	+4.345	<.001	<.001	3	1
UCEC	RN7SL237P →	+0.273	+3.496	.005	<.001	3	1
UCEC	MIR3192 →	+0.706	+3.184	<.001	.001	3	1
UCEC	TBC1D29P →	+0.080	+3.544	.002	.005	3	1
UCEC	LGALS9DP →	+0.315	+3.031	<.001	.005	3	1
UCEC	ATP5MGP6 →	+0.309	+3.097	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

RN7SL592P by AP2S1 expression — UCEC

Explore this box plot interactively →