AP2S1

Across TCGA patient cohorts, AP2S1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP2S1-associated genes across cancer lineages are PRAS40_pT246, Tuberin_pT1462, and Tuberin. Each is linked with AP2S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP2S1-to-partner and partner-to-AP2S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by AP2S1-low versus AP2S1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2S1→partner) and Y-score (partner→AP2S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.286	+3.013	.003	.019	3	1
UCEC	Tuberin_pT1462 →	+0.381	+2.817	.004	.036	3	1
UCEC	Tuberin →	+0.455	+3.000	.003	.037	3	1
UCEC	ATM →	-0.773	-3.000	.003	.037	3	1
UCEC	MEK1 →	+0.558	+3.000	.008	.037	2	1
UCEC	Di-Ras3 →	-0.241	-3.000	.004	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PRAS40_pT246 by AP2S1 expression — UCEC

Explore this box plot interactively →