AP2S1

Across TCGA cell cohorts, AP2S1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,771 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AP2S1-associated GO terms across cancer lineages are Negative regulation of hyaluronan biosynthetic process, Negative regulation of calcium ion export across plasma membrane, and Detection of calcium ion. Each is linked with AP2S1 in more than 11 cancer types. Because this analysis shows association rather than direction, both AP2S1-to-partner and partner-to-AP2S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hyaluronan biosynthetic process grouped by AP2S1-low versus AP2S1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2S1→partner) and Y-score (partner→AP2S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of hyaluronan biosynthetic process →	+0.194	+0.705	<.001	<.001	3	12
CNS	Negative regulation of calcium ion export across plasma membrane →	+0.066	+0.853	.006	.001	3	10
BONE	Detection of calcium ion →	+0.218	+0.636	<.001	<.001	3	10
BONE	Negative regulation of Rho protein signal transduction →	+0.169	+0.761	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Cellular response to insulin-like growth factor stimulus →	+0.213	+1.025	<.001	<.001	3	9
SOFT_TISSUE	Establishment or maintenance of cytoskeleton polarity →	+0.207	+0.828	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,771 associations by consensus.

Negative regulation of hyaluronan biosynthetic process by AP2S1 expression — LIVER

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