AP2A2

Across TCGA cell cohorts, AP2A2 mutation is significantly associated with the RNA expression of many other genes, with 758 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP2A2-associated genes across cancer lineages are LRRC3C, KRT32, and ANKRD60. Each is linked with AP2A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP2A2-to-partner and partner-to-AP2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by AP2A2-low versus AP2A2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2A2→partner) and Y-score (partner→AP2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRRC3C →	+0.147	+4.118	<.001	.001	3	2
BLOOD_Myeloma	KRT32 →	+0.005	+3.285	<.001	.009	3	1
STOMACH	ANKRD60 →	+0.022	+4.285	<.001	.007	3	1
SKIN	KRTAP5-4 →	+0.101	+4.977	<.001	.007	3	1
OVARY	LCE6A →	+0.032	+4.807	<.001	.003	3	1
LARGE_INTESTINE	PICK1 →	+0.615	+2.628	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 758 associations by consensus.

LRRC3C by AP2A2 expression — BLOOD_Leukemia

Explore this box plot interactively →