AP1S1

Across TCGA cell cohorts, AP1S1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,719 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible AP1S1-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Carnitine metabolic process, and Regulation of intestinal lipid absorption. Each is linked with AP1S1 in more than 10 cancer types. Because this analysis shows association rather than direction, both AP1S1-to-partner and partner-to-AP1S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by AP1S1-low versus AP1S1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1S1→partner) and Y-score (partner→AP1S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of isotype switching to IgG isotypes →	+0.132	+0.850	<.001	.005	3	11
UPPER_AERODIGESTIVE_TRACT	Carnitine metabolic process →	+0.112	+1.019	.001	<.001	3	7
SKIN	Regulation of intestinal lipid absorption →	+0.312	+0.548	.009	.002	3	7
SKIN	Regulation of isotype switching to IgG isotypes →	+0.116	+0.818	<.001	<.001	3	7
STOMACH	Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage →	-0.103	-0.855	.002	.007	3	6
SKIN	Pre-mRNA catabolic process →	+0.139	+0.605	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,719 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by AP1S1 expression — BONE

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