AP1S1

Across TCGA pan-cancer cohorts, AP1S1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated AP1S1 data layer compared with 1 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher AP1S1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AP1S1 expression acts as an unfavorable survival marker, although some lineages such as STAD and KIRC show a favorable association.

KICH, STAD, and HNSC are the cancer types where AP1S1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	II,III,IV	0.605	1.000	<.001	107	view →
STAD	DFS	Quartile	II,III,IV	0.624	0.388	.001	93	view →
HNSC	DFS	Tertile	All	0.630	0.764	<.001	90	view →
BRCA	DFS	Tertile	All	0.866	0.934	<.001	69	view →
ACC	DFS	Median	All	0.249	0.670	<.001	64	view →
UVM	DFS	Quartile	II,III,IV	0.497	0.859	.004	52	view →
SARC	OS	Tertile	All	0.633	0.827	<.001	26	view →
PRAD	DFS	Quartile	All	0.864	0.960	.003	20	view →
LIHC	OS	Median	III,IV	0.459	0.739	.006	18	view →
CESC	DFS	Quartile	All	0.615	0.814	.004	18	view →
KIRC	DFS	Quartile	All	0.809	0.521	.003	18	view →
THCA	DFS	Median	III,IV	0.260	0.856	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

AP1S1–KICH (OS)

Open the KICH breakdown →