AP1S1

Across TCGA cell cohorts, AP1S1 mutation is significantly associated with the RNA expression of many other genes, with 219 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP1S1-associated genes across cancer lineages are GCAT, EIF3L, and TRMU. Each is linked with AP1S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP1S1-to-partner and partner-to-AP1S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by AP1S1-low versus AP1S1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1S1→partner) and Y-score (partner→AP1S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.501	+3.502	<.001	.001	3	1
LARGE_INTESTINE	EIF3L →	+0.639	+3.502	<.001	.001	3	1
LARGE_INTESTINE	TRMU →	+0.654	+3.502	<.001	.001	3	1
LARGE_INTESTINE	DDHD1 →	+0.755	+3.502	.001	.001	3	1
LARGE_INTESTINE	CAB39L →	-1.428	-3.416	.002	.002	3	1
LARGE_INTESTINE	C1QBP →	+0.678	+3.169	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 219 associations by consensus.

GCAT by AP1S1 expression — LARGE_INTESTINE

Explore this box plot interactively →