AOX1

Across TCGA pan-cancer cohorts, AOX1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AOX1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AOX1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AOX1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, GBM, and CCRCC are the cancer types where AOX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.780	0.453	.001	15	view →
GBM	OS	Tertile	All	0.316	0.609	.005	12	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	11	view →
LSCC	DFS	Median	All	0.907	0.464	.009	3	view →
HNSC	DFS	Tertile	All	0.923	0.976	.042	3	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AOX1–LUAD (DFS)

Open the LUAD breakdown →