AOX1

Across TCGA pan-cancer cohorts, AOX1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of AOX1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where AOX1 RNA is repressed in tumor relative to normal tissue. In most cancer types AOX1 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and KIRP are the cancer types where AOX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AOX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−4.317	<.001	11	view →
THCA	All	IV	−4.107	<.001	11	view →
KIRP	All	III,IV	−3.485	<.001	11	view →
LUAD	Male	II,III,IV	−1.807	<.001	11	view →
COAD	Female	All	−1.275	<.001	9	view →
LUSC	Female	All	−2.532	<.001	8	view →
HNSC	Male	IV	−2.028	<.001	8	view →
KICH	Male	II,III,IV	−4.461	<.001	7	view →
UCEC	All	III,IV	−3.967	<.001	6	view →
BRCA	All	III,IV	−2.428	<.001	6	view →
KIRC	Female	IV	−2.810	<.001	5	view →
LIHC	Female	All	−2.323	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

AOX1–BLCA

Open the BLCA breakdown →