AOX1

Across TCGA patient cohorts, AOX1 mutation is significantly associated with the RNA expression of many other genes, with 7,454 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AOX1-associated genes across cancer lineages are SPC24, DTYMK, and PPP2R2D. Each is linked with AOX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AOX1-to-partner and partner-to-AOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPC24 grouped by AOX1-low versus AOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOX1→partner) and Y-score (partner→AOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPC24 →	+0.491	+1.628	.002	<.001	3	4
UCEC	DTYMK →	+0.501	+2.273	<.001	<.001	3	4
UCEC	PPP2R2D →	+0.275	+2.200	<.001	<.001	3	4
UCEC	CTDNEP1 →	+0.310	+1.839	<.001	<.001	3	4
UCEC	POLE2 →	+0.590	+1.649	<.001	<.001	3	4
UCEC	PIMREG →	+0.721	+1.828	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,454 associations by consensus.

SPC24 by AOX1 expression — UCEC

Explore this box plot interactively →