AOX1

Across TCGA patient cohorts, AOX1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AOX1-associated genes across cancer lineages are ATM, Myosin-IIa_pS1943, and 14-3-3_beta. Each is linked with AOX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AOX1-to-partner and partner-to-AOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by AOX1-low versus AOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOX1→partner) and Y-score (partner→AOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.398	-2.401	.002	.002	3	4
COAD	Myosin-IIa_pS1943 →	+0.473	+2.832	.014	.035	3	3
UCEC	14-3-3_beta →	-0.072	-1.558	.014	.032	3	3
UCEC	eIF4E →	+0.169	+2.920	.005	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.128	-1.247	.009	.041	3	3
UCEC	TFRC →	+0.362	+1.906	.019	.014	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ATM by AOX1 expression — UCEC

Explore this box plot interactively →