AOX1

Across TCGA cell cohorts, AOX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,438 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AOX1-associated GO terms across cancer lineages are Peptidyl-lysine oxidation, Response to vitamin K, and Positive regulation of cell-substrate junction organization. Each is linked with AOX1 in more than 13 cancer types. Because this analysis shows association rather than direction, both AOX1-to-partner and partner-to-AOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-lysine oxidation grouped by AOX1-low versus AOX1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AOX1→partner) and Y-score (partner→AOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Peptidyl-lysine oxidation →	+1.551	+2.239	<.001	.004	3	14
BONE	Response to vitamin K →	+1.723	+2.904	<.001	<.001	3	14
BONE	Positive regulation of cell-substrate junction organization →	+0.144	+2.263	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of Rho protein signal transduction →	+0.188	+3.954	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Regulation of plasminogen activation →	+0.296	+3.137	<.001	<.001	3	12
BONE	Negative regulation of plasminogen activation →	+1.109	+2.775	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,438 associations by consensus.

Peptidyl-lysine oxidation by AOX1 expression — STOMACH

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