AOX1

Across TCGA cell cohorts, AOX1 mutation is significantly associated with the RNA expression of many other genes, with 784 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AOX1-associated genes across cancer lineages are OR9A4, OR52B4, and SLC13A1. Each is linked with AOX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AOX1-to-partner and partner-to-AOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A4 grouped by AOX1-low versus AOX1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOX1→partner) and Y-score (partner→AOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR9A4 →	+0.029	+3.491	.001	.008	3	3
BLOOD_Myeloma	OR52B4 →	+0.015	+3.169	<.001	.004	3	2
PANCREAS	SLC13A1 →	+0.012	+4.029	<.001	.007	3	2
BLOOD_Leukemia	INSM2 →	+0.136	+4.354	.003	<.001	3	2
BLOOD_Leukemia	PRR30 →	+0.010	+3.269	<.001	.007	3	2
OVARY	CCR8 →	+0.150	+4.070	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 784 associations by consensus.

OR9A4 by AOX1 expression — PANCREAS

Explore this box plot interactively →