AOC3

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, AOC3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,495 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AOC3-associated genes across cancer lineages are CHRDL1, DCN, and CNRIP1. Each is linked with AOC3 in more than 8 cancer types. Because this analysis shows association rather than direction, both AOC3-to-partner and partner-to-AOC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AOC3 versus CHRDL1 in BRCA, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC3→partner) and Y-score (partner→AOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCACHRDL1 →+1.802+0.939<.001<.00139
CCRCCDCN →+2.166+0.565<.001<.00139
UCECCNRIP1 →+0.888+0.689<.001<.00139
OVCDO1 →+1.555+1.027<.001<.00139
COADMYH11 →+1.870+0.732<.001<.00139
CCRCCFBLN5 →+1.256+0.541<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 15,495 associations by consensus.

AOC3 vs CHRDL1 — BRCA

Per-sample scatter of AOC3 vs CHRDL1 in BRCA (Pearson r = 0.68).

Explore this scatter interactively →

Exploration