AOC3

Across TCGA pan-cancer cohorts, AOC3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated AOC3 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher AOC3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AOC3 expression acts as an unfavorable survival marker, although some lineages such as UCS and SARC show a favorable association.

KIRP, LUSC, and ACC are the cancer types where AOC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.374	0.703	.002	96	view →
LUSC	OS	Quartile	All	0.294	0.509	<.001	69	view →
ACC	DFS	Median	II,III,IV	0.388	0.680	.003	54	view →
UCS	DFS	Quartile	III,IV	0.571	0.282	.005	46	view →
UVM	DFS	Median	All	0.446	0.697	.003	37	view →
BLCA	OS	Median	II,III,IV	0.346	0.547	.005	34	view →
COAD	DFS	Tertile	All	0.306	0.585	.002	33	view →
MESO	OS	Quartile	All	0.331	0.602	.002	30	view →
SARC	OS	Tertile	All	0.845	0.635	<.001	27	view →
THCA	DFS	Tertile	All	0.939	0.670	.001	25	view →
LUAD	OS	Quartile	II,III,IV	0.751	0.475	.001	24	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

AOC3–KIRP (OS)

Open the KIRP breakdown →