AOC3

Across TCGA patient cohorts, AOC3 mutation is significantly associated with the RNA expression of many other genes, with 2,486 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible AOC3-associated genes across cancer lineages are ITGAE, CHRNA5, and SKA2. Each is linked with AOC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AOC3-to-partner and partner-to-AOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAE grouped by AOC3-low versus AOC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC3→partner) and Y-score (partner→AOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGAE →	+0.345	+2.243	.001	.005	3	3
SKCM	CHRNA5 →	+0.629	+4.025	<.001	<.001	3	3
SKCM	SKA2 →	+0.601	+1.842	<.001	<.001	3	3
SKCM	C4orf46 →	+0.498	+3.919	<.001	<.001	3	3
SKCM	BIRC5 →	+0.767	+2.134	<.001	<.001	3	3
SKCM	CDC7 →	+0.543	+2.832	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,486 associations by consensus.

ITGAE by AOC3 expression — UCEC

Explore this box plot interactively →