AOC3

Across TCGA patient cohorts, AOC3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AOC3-associated genes across cancer lineages are Cyclin-B1, p90 RSK, and PTEN. Each is linked with AOC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AOC3-to-partner and partner-to-AOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by AOC3-low versus AOC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC3→partner) and Y-score (partner→AOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.637	+2.807	.001	.002	3	3
UCEC	p90 RSK →	+0.144	+1.676	.033	.007	3	2
UCEC	PTEN →	-0.297	-2.000	.034	.030	3	2
UCEC	4E-BP1 →	+0.278	+1.515	.003	.033	3	2
COAD	p70-S6K →	+0.370	+2.832	.008	.035	3	1
SKCM	ACC_pS79 →	+0.231	+1.906	.047	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Cyclin-B1 by AOC3 expression — UCEC

Explore this box plot interactively →