AOC3

Across TCGA cell cohorts, AOC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,320 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AOC3-associated GO terms across cancer lineages are mRNA catabolic process, Negative regulation of transcription elongation by RNA polymerase II, and DNA topological change. Each is linked with AOC3 in more than 10 cancer types. Because this analysis shows association rather than direction, both AOC3-to-partner and partner-to-AOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA catabolic process grouped by AOC3-low versus AOC3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC3→partner) and Y-score (partner→AOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	mRNA catabolic process →	+0.058	+1.125	<.001	<.001	3	11
PANCREAS	Negative regulation of transcription elongation by RNA polymerase II →	+0.111	+0.877	<.001	<.001	3	10
OESOPHAGUS	DNA topological change →	+0.110	+1.023	.001	.001	3	10
OESOPHAGUS	Nuclear-transcribed mRNA catabolic process →	+0.072	+1.339	<.001	<.001	3	9
OESOPHAGUS	Cytoplasmic translation →	+0.112	+1.661	<.001	<.001	3	9
OESOPHAGUS	Regulation of signal transduction by p53 class mediator →	+0.049	+1.111	.004	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,320 associations by consensus.

mRNA catabolic process by AOC3 expression — OESOPHAGUS

Explore this box plot interactively →