AOC3

Across TCGA cell cohorts, AOC3 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AOC3-associated genes across cancer lineages are LGK974, GSK3337463A, and 741909. Each is linked with AOC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AOC3-to-partner and partner-to-AOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGK974 grouped by AOC3-low versus AOC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC3→partner) and Y-score (partner→AOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LGK974 →	+0.371	+2.868	.016	.022	3	1
LARGE_INTESTINE	GSK3337463A →	+0.386	+2.684	.016	.035	3	1
LARGE_INTESTINE	741909 →	+0.550	+2.871	.029	.021	3	1
LARGE_INTESTINE	Sepantronium bromide →	-0.820	-2.743	.016	.046	3	1
LARGE_INTESTINE	IC-87114 →	+0.264	+2.874	.006	.021	3	1
LARGE_INTESTINE	Torin 2 →	+0.555	+2.877	.029	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

LGK974 by AOC3 expression — LARGE_INTESTINE

Explore this box plot interactively →