AOC2

Across TCGA patient cohorts, AOC2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AOC2-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and ACC1. Each is linked with AOC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both AOC2-to-partner and partner-to-AOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AOC2-low versus AOC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC2→partner) and Y-score (partner→AOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.556	+3.008	<.001	.019	2	4
UCEC	EGFR_pY1068 →	-0.214	-2.321	.030	.033	3	2
UCEC	ACC1 →	+0.295	+1.584	.039	.036	3	2
UCEC	Caspase-8 →	-0.247	-3.673	.012	.001	3	2
UCEC	14-3-3_beta →	-0.105	-3.295	.007	.009	3	1
UCEC	A-Raf_pS299 →	-0.172	-2.115	<.001	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by AOC2 expression — COAD

Explore this box plot interactively →