AOC2

Across TCGA pan-cancer cohorts, AOC2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AOC2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where AOC2 RNA is repressed in tumor relative to normal tissue. In most cancer types AOC2 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

LUAD, LIHC, and COAD are the cancer types where AOC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AOC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.893	<.001	7	view →
LIHC	Female	All	+0.513	<.001	7	view →
COAD	Female	All	+0.451	<.001	7	view →
BRCA	All	III,IV	−1.495	<.001	6	view →
READ	Male	All	+0.483	.005	6	view →
LUSC	Female	All	−0.779	<.001	5	view →
HNSC	Male	II,III,IV	+0.300	.025	4	view →
THCA	Female	All	−0.292	<.001	4	view →
CHOL	Male	All	+1.133	<.001	3	view →
PAAD	Male	All	−0.815	.026	2	view →
PRAD	All	All	+0.235	.002	2	view →
KICH	Female	All	−0.355	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AOC2–LUAD

Open the LUAD breakdown →