AOC2

Across TCGA cell cohorts, AOC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,288 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AOC2-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription, elongation, Negative regulation of transcription elongation by RNA polymerase II, and Positive regulation of translation. Each is linked with AOC2 in more than 10 cancer types. Because this analysis shows association rather than direction, both AOC2-to-partner and partner-to-AOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription, elongation grouped by AOC2-low versus AOC2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC2→partner) and Y-score (partner→AOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of DNA-templated transcription, elongation →	+0.103	+0.904	<.001	<.001	3	11
LIVER	Negative regulation of transcription elongation by RNA polymerase II →	+0.107	+0.878	<.001	<.001	3	11
OESOPHAGUS	Positive regulation of translation →	+0.065	+1.561	.002	<.001	3	10
LUNG_NSCLC_LUSC	Leukotriene signaling pathway →	+1.473	+1.728	<.001	.001	3	10
STOMACH	Calcium-independent cell-matrix adhesion →	+0.233	+0.837	<.001	.006	3	9
OVARY	miRNA metabolic process →	+0.106	+0.747	<.001	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,288 associations by consensus.

Negative regulation of DNA-templated transcription, elongation by AOC2 expression — PANCREAS

Explore this box plot interactively →