AOC2

Across TCGA cell cohorts, AOC2 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AOC2-associated genes across cancer lineages are NPAP1, CSTL1, and PLCZ1. Each is linked with AOC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AOC2-to-partner and partner-to-AOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAP1 grouped by AOC2-low versus AOC2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC2→partner) and Y-score (partner→AOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NPAP1 →	+0.050	+4.867	.001	.009	3	2
BLOOD_Lymphoma	CSTL1 →	+0.549	+4.867	<.001	.009	3	2
BLOOD_Lymphoma	PLCZ1 →	+0.169	+5.643	<.001	.002	3	2
LUNG_NSCLC_LUAD	LCE1B →	+0.037	+4.371	<.001	.005	3	1
SKIN	CCDC172 →	+0.004	+4.415	<.001	.007	3	1
SKIN	KRTAP5-5 →	+0.017	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

NPAP1 by AOC2 expression — BLOOD_Lymphoma

Explore this box plot interactively →