AOC1

Across TCGA pan-cancer cohorts, AOC1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AOC1 data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AOC1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated AOC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, PAAD, and UCEC are the cancer types where AOC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	IV	0.045	0.717	<.001	20	view →
PAAD	OS	Median	All	0.112	0.640	.004	12	view →
UCEC	DFS	Median	All	0.957	0.827	.020	12	view →
SARC	DFS	Median	All	0.179	0.612	.024	6	view →
LGG	OS	Median	All	0.544	0.909	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AOC1–LUAD (DFS)

Open the LUAD breakdown →