AOC1

Across TCGA pan-cancer cohorts, AOC1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of AOC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AOC1 RNA is repressed in tumor relative to normal tissue. In most cancer types AOC1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and LUAD are the cancer types where AOC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AOC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−6.914	<.001	11	view →
COAD	Female	All	−2.050	<.001	11	view →
LUAD	Female	II,III,IV	+2.808	<.001	9	view →
THCA	All	II,III,IV	+1.347	<.001	9	view →
KIRP	Male	II,III,IV	−4.418	<.001	8	view →
READ	All	All	−1.657	<.001	7	view →
STAD	All	All	+2.361	.001	6	view →
UCEC	All	All	+1.677	.001	6	view →
KIRC	Male	All	−1.095	.006	6	view →
BRCA	Female	II,III,IV	+0.509	<.001	6	view →
LIHC	All	All	−0.862	.001	4	view →
ESCA	All	II,III,IV	+4.420	.009	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

AOC1–KICH

Open the KICH breakdown →