AOC1

Across TCGA pan-cancer cohorts, AOC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AOC1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher AOC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AOC1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, COAD, and LUAD are the cancer types where AOC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.546	0.204	<.001	57	view →
COAD	DFS	Median	All	1.000	0.886	.019	54	view →
LUAD	DFS	Median	III,IV	0.307	0.732	<.001	28	view →
LSCC	OS	Median	III,IV	0.855	0.413	.009	9	view →
CCRCC	DFS	Tertile	All	1.000	0.709	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AOC1–PDAC (DFS)

Open the PDAC breakdown →