AOC1

Across TCGA patient cohorts, AOC1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,653 significant associations in total. COAD shows the largest number of these associations.

The most reproducible AOC1-associated genes across cancer lineages are CD109, CTHRC1, and TMEM176A. Each is linked with AOC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both AOC1-to-partner and partner-to-AOC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AOC1 versus CD109 in LUAD, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC1→partner) and Y-score (partner→AOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CD109 →	-0.909	-0.738	.001	.002	3	5
COAD	CTHRC1 →	-1.262	-0.473	.001	<.001	3	5
BRCA	TMEM176A →	+1.774	+1.429	.003	.001	3	5
COAD	MAD2L2 →	-0.563	-0.551	<.001	<.001	3	4
LUAD	COLGALT1 →	-0.554	-0.627	<.001	.001	3	4
LUAD	DDC →	+1.710	+1.033	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,653 associations by consensus.

AOC1 vs CD109 — LUAD

Explore this scatter interactively →