AOC1

Across TCGA patient cohorts, AOC1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AOC1-associated genes across cancer lineages are 14-3-3_zeta, GAPDH, and GATA3. Each is linked with AOC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AOC1-to-partner and partner-to-AOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_zeta grouped by AOC1-low versus AOC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC1→partner) and Y-score (partner→AOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	14-3-3_zeta →	+0.148	+3.459	.026	.004	3	3
SKCM	GAPDH →	+0.441	+1.584	.018	.032	3	2
SKCM	GATA3 →	-0.128	-1.289	.036	.022	3	2
UCEC	Mre11 →	-0.069	-1.415	.009	.010	3	2
UCEC	p62 Lck ligand →	+0.258	+2.179	.010	.001	3	2
UCEC	ATM →	-0.625	-2.649	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

14-3-3_zeta by AOC1 expression — SKCM

Explore this box plot interactively →