AOC1

Across TCGA cell cohorts, AOC1 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AOC1-associated genes across cancer lineages are CPXCR1, CLEC9A, and IL19. Each is linked with AOC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AOC1-to-partner and partner-to-AOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPXCR1 grouped by AOC1-low versus AOC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOC1→partner) and Y-score (partner→AOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CPXCR1 →	+0.054	+2.971	.004	.008	3	2
PANCREAS	CLEC9A →	+0.568	+3.786	.001	.004	3	1
CNS	IL19 →	+0.058	+3.297	<.001	.001	3	1
CNS	ZNF729 →	+0.343	+3.141	<.001	.004	3	1
CNS	KRTAP4-1 →	+0.160	+2.611	<.001	.009	3	1
CNS	ZNF99 →	+0.103	+2.823	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

CPXCR1 by AOC1 expression — BLOOD_Leukemia

Explore this box plot interactively →