AOAH-IT1

Across TCGA pan-cancer cohorts, AOAH-IT1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated AOAH-IT1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher AOAH-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AOAH-IT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and THCA show a favorable association.

UCS, LUAD, and MESO are the cancer types where AOAH-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	II,III,IV	0.208	0.637	.005	54	view →
LUAD	DFS	Median	All	0.380	0.296	.004	44	view →
MESO	OS	Tertile	III,IV	0.278	0.452	.013	37	view →
THYM	OS	Tertile	III,IV	0.229	1.000	<.001	31	view →
THCA	DFS	Tertile	II,III,IV	1.000	0.699	.009	27	view →
LUSC	DFS	Median	All	0.792	0.699	.003	27	view →
SKCM	OS	Tertile	All	0.934	0.829	.003	25	view →
ESCA	DFS	Tertile	All	0.617	0.423	.011	21	view →
KIRC	DFS	Median	All	0.558	0.684	.002	21	view →
LAML	DFS	Median	All	0.704	0.444	.011	18	view →
ACC	OS	Tertile	III,IV	0.269	0.787	<.001	18	view →
UVM	OS	Tertile	All	0.371	0.707	.044	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

AOAH-IT1–UCS (OS)

Open the UCS breakdown →