AOAH-IT1

Across TCGA pan-cancer cohorts, AOAH-IT1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of AOAH-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AOAH-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AOAH-IT1 is over-expressed in tumor, although a few such as UCEC and LUAD show the opposite, repressed pattern.

KIRC, STAD, and COAD are the cancer types where AOAH-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AOAH-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.144	<.001	10	view →
STAD	Male	III,IV	+0.265	.002	6	view →
COAD	All	All	+0.246	.008	4	view →
READ	Female	All	+1.064	.004	2	view →
HNSC	All	IV	+0.086	.014	2	view →
UCEC	All	All	−0.056	.023	2	view →
LUAD	All	III,IV	−0.112	.022	1	view →
LIHC	Male	All	−0.051	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

AOAH-IT1–KIRC

Open the KIRC breakdown →