ANXA8

Across TCGA patient cohorts, ANXA8 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANXA8-associated genes across cancer lineages are eIF4E, 14-3-3_beta, and XBP1. Each is linked with ANXA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANXA8-to-partner and partner-to-ANXA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ANXA8-low versus ANXA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANXA8→partner) and Y-score (partner→ANXA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.186	+2.087	.021	.005	3	3
SARC	14-3-3_beta →	-0.205	-3.143	.026	.016	3	2
BRCA	XBP1 →	-0.319	-2.993	.021	.038	3	2
UCEC	S6_pS240_S244 →	+0.487	+2.000	.001	.030	3	2
UCEC	ASNS →	+0.444	+3.321	.001	.009	3	2
UCEC	BRD4 →	+0.264	+2.999	.012	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

eIF4E by ANXA8 expression — UCEC

Explore this box plot interactively →