ANXA8

Across TCGA pan-cancer cohorts, ANXA8 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ANXA8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ANXA8 RNA is repressed in tumor relative to normal tissue. In most cancer types ANXA8 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

LUAD, BRCA, and LUSC are the cancer types where ANXA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANXA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−1.567	<.001	8	view →
BRCA	All	III,IV	−0.931	<.001	8	view →
LUSC	Male	All	+1.733	<.001	7	view →
LIHC	Male	III,IV	−0.353	<.001	5	view →
HNSC	All	All	+0.777	.009	4	view →
THCA	All	All	+0.255	.001	3	view →
KICH	Male	II,III,IV	−0.012	.020	3	view →
BLCA	Male	IV	+3.815	.023	2	view →
PAAD	All	All	+3.000	.005	2	view →
PRAD	All	All	−0.906	<.001	2	view →
KIRC	Male	All	+0.131	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ANXA8–LUAD

Open the LUAD breakdown →