ANXA7

Across TCGA patient cohorts, ANXA7 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANXA7-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1068, and ERK2. Each is linked with ANXA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANXA7-to-partner and partner-to-ANXA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ANXA7-low versus ANXA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANXA7→partner) and Y-score (partner→ANXA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.157	-1.807	.010	.027	3	2
UCEC	EGFR_pY1068 →	-0.218	-1.807	.035	.027	3	1
UCEC	ERK2 →	+0.214	+2.999	.007	.035	3	1
UCEC	Gab2 →	+0.320	+2.999	.029	.035	3	1
UCEC	INPP4B →	-0.339	-2.308	.011	.006	3	1
UCEC	Mre11 →	-0.078	-2.973	.026	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

mTOR_pS2448 by ANXA7 expression — UCEC

Explore this box plot interactively →