ANXA7

Across TCGA pan-cancer cohorts, ANXA7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ANXA7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ANXA7 RNA is repressed in tumor relative to normal tissue. In most cancer types ANXA7 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, LIHC, and HNSC are the cancer types where ANXA7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANXA7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.557	<.001	9	view →
LIHC	All	III,IV	+0.652	<.001	9	view →
HNSC	All	III,IV	+0.539	<.001	9	view →
BLCA	All	All	−0.407	.003	6	view →
KIRC	Male	All	−0.304	<.001	6	view →
THCA	Male	III,IV	−0.305	.001	5	view →
STAD	All	II,III,IV	+0.493	.003	4	view →
UCEC	All	All	−0.435	.021	2	view →
READ	All	All	−0.348	.004	2	view →
LUAD	Male	All	+0.279	.002	2	view →
BRCA	All	II,III,IV	+0.139	.020	2	view →
CHOL	All	All	+0.934	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ANXA7–KICH

Open the KICH breakdown →