ANXA5

Across TCGA patient cohorts, ANXA5 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANXA5-associated genes across cancer lineages are GATA6, JNK2, and Caspase-8. Each is linked with ANXA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANXA5-to-partner and partner-to-ANXA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by ANXA5-low versus ANXA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANXA5→partner) and Y-score (partner→ANXA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.165	-2.314	.033	.035	3	1
UCEC	JNK2 →	+0.237	+2.834	.010	.034	3	1
UCEC	Caspase-8 →	-0.259	-3.295	.027	.009	3	1
UCEC	MEK1 →	+0.431	+2.584	.011	.011	2	1
UCEC	P-Cadherin →	-0.152	-2.990	.023	.036	2	1
UCEC	Rad50 →	-0.251	-2.584	.026	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GATA6 by ANXA5 expression — UCEC

Explore this box plot interactively →