ANXA5

Across TCGA pan-cancer cohorts, ANXA5 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ANXA5 data layer compared with 4 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher ANXA5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ANXA5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and THCA show a favorable association.

STAD, BLCA, and UCEC are the cancer types where ANXA5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	All	0.518	0.686	.002	110	view →
BLCA	OS	Median	All	0.545	0.672	.001	89	view →
UCEC	DFS	Tertile	III,IV	0.865	0.705	.001	78	view →
LIHC	OS	Median	All	0.409	0.604	<.001	63	view →
HNSC	OS	Tertile	All	0.558	0.720	<.001	61	view →
LGG	OS	Median	All	0.340	0.551	<.001	53	view →
UVM	DFS	Tertile	II,III,IV	0.353	0.779	.003	52	view →
LUSC	DFS	Median	All	0.307	0.467	.001	50	view →
THCA	DFS	Tertile	III,IV	1.000	0.385	<.001	47	view →
ESCA	OS	Tertile	All	0.661	0.354	.001	45	view →
CESC	DFS	Quartile	All	0.402	0.668	.003	34	view →
MESO	OS	Tertile	All	0.463	0.695	.005	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ANXA5–STAD (OS)

Open the STAD breakdown →