ANTXR2

Across TCGA pan-cancer cohorts, ANTXR2 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ANTXR2 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher ANTXR2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANTXR2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

MESO, LGG, and ACC are the cancer types where ANTXR2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.264	0.480	.003	55	view →
LGG	DFS	Median	All	0.762	0.905	<.001	54	view →
ACC	DFS	Tertile	All	0.476	0.880	.006	53	view →
HNSC	OS	Median	All	0.703	0.797	.006	43	view →
KIRC	DFS	Tertile	All	0.896	0.694	<.001	41	view →
SKCM	OS	Median	All	0.383	0.284	<.001	37	view →
LUSC	OS	Median	II,III,IV	0.294	0.530	.001	31	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	28	view →
PAAD	OS	Tertile	All	0.250	0.533	.001	26	view →
CESC	DFS	Median	All	0.665	0.810	.003	24	view →
CHOL	DFS	Median	All	0.716	0.110	<.001	22	view →
DLBC	DFS	Median	All	0.643	1.000	.021	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ANTXR2–MESO (DFS)

Open the MESO breakdown →