ANTXR2

Across TCGA pan-cancer cohorts, ANTXR2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ANTXR2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ANTXR2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANTXR2 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where ANTXR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANTXR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.383	<.001	11	view →
BLCA	Male	III,IV	−2.681	<.001	10	view →
COAD	Female	All	−1.198	<.001	9	view →
KIRC	Male	All	+0.608	<.001	8	view →
KIRP	All	All	−0.709	<.001	7	view →
THCA	All	II,III,IV	−0.662	<.001	7	view →
UCEC	All	All	−3.242	<.001	6	view →
BRCA	All	II,III,IV	−1.227	<.001	6	view →
KICH	Female	All	−1.952	<.001	5	view →
LUSC	All	II,III,IV	−0.859	<.001	5	view →
READ	Female	All	−2.286	<.001	3	view →
LIHC	All	All	−0.503	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ANTXR2–HNSC

Open the HNSC breakdown →