ANP32E

Across TCGA pan-cancer cohorts, ANP32E mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ANP32E data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ANP32E mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANP32E expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

HNSC, COAD, and GBM are the cancer types where ANP32E mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.507	0.760	<.001	68	view →
COAD	DFS	Median	All	0.915	1.000	.009	60	view →
GBM	OS	Median	All	0.504	0.266	.001	16	view →
CCRCC	DFS	Quartile	All	1.000	0.737	.026	14	view →
PDAC	DFS	Quartile	III,IV	0.177	0.915	.010	8	view →
LSCC	OS	Median	II,III,IV	0.847	0.630	.034	7	view →
OV	DFS	Median	All	0.716	1.000	.049	4	view →
UCEC	DFS	Median	All	1.000	0.938	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ANP32E–HNSC (DFS)

Open the HNSC breakdown →